Bayesian calibration as proposed by Kennedy and O’Hagan  has been increasingly applied to building energy models due to its ability to account for the discrepancy between observed values and model predictions. However, its application has been limited to calibration using monthly aggregated data because it is computationally inefficient when the dataset is large. This study focuses on improvements to the current implementation of Bayesian calibration to building energy simulation. This is achieved by: (1) using information theory to select a representative subset of the entire dataset for the calibration, and (2) using a more effective Markov chain Monte Carlo (MCMC) algorithm, the No-U-Turn Sampler (NUTS), which is an extension of Hamiltonian Monte Carlo (HMC) to explore the posterior distribution. The calibrated model was assessed by evaluating both accuracy and convergence. Application of the proposed method is demonstrated using two cases studies: (1) a TRNSYS model of a water-cooled chiller in a mixed-use building in Singapore, and (2) an EnergyPlus model of the cooling system of an office building in Pennsylvania, U.S.A. In both case studies, convergence was achieved for all parameters of the posterior distribution, with Gelman–Rubin statistics Rˆ within 1±0.1. The coefficient of variation of the root mean squared error (CVRMSE) and normalized mean biased error (NMBE) were also within the thresholds set by ASHRAE Guideline 14 .